Strategy for tumor targeting by macromolecule-drug conjugates.
نویسندگان
چکیده
منابع مشابه
Drug delivery systems based on sugar-macromolecule conjugates.
The specificity of carbohydrate-protein interactions can greatly outstrip that of many other ligand-binding systems; such is the enormous density of information that sugars can convey. In addition, macromolecules allow for the fine-tuning of active drug delivery through their great ability to undergo site-specific modification and their inherent physicochemical properties. Once combined, these ...
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Peptides containing the asparagine-glycine-arginine (NGR) motif are recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature. Spontaneous decomposition of NGR peptides can result in isoAsp derivatives, which are recognized by RGD-binding integrins that are essential for tumor metastasis. Peptides binding to CD13 and RGD-binding integ...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 1988
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.3.405